Image: ©Gates Archive/Dominique CattonExperts cite many potential reasons for this poor immune response-for example, intestinal inflammation or gut microbiome alterations resulting from lifestyle-related or environmental factors. While the oral rotavirus vaccine has been shown to dramatically reduce diarrheal hospitalizations and deaths in children under 5, it has also proven to be much less effective in low-income settings compared to high-income ones. But while successful vaccination represents the most expeditious and practical way to reduce the impact of these infections in the developing world, a major obstacle remains: Oral vaccines do not provide the same level of protection in low-income settings as they do in high-income settings. Harvard COVID-19 Information: Keep Harvard HealthyĮach year, diarrhea-usually a symptom of an infection in the intestinal tract-kills about 525,000 children under the age of 5, according to the World Health Organization.Celebrating 50 Years of Diversity and Inclusion.Research Departments, Centers, Initiatives and more.
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